Non-prescription medications for sinusitis

Medications available without a prescription may help relieve pain and promote sinus drainage.

  • Try pain relievers such as ASA, ibuprofen, or acetaminophen to relieve facial pain and headache. Do not give ASA to anyone under age 20 because of the risk of Reye's syndrome.
  • Try using a decongestant nasal spray or decongestant nose drops. Avoid using these products for more than 3 days in a row because it increases your risk of developing “rebound” nasal congestion. Frequent, prolonged use of a nasal decongestant can actually prolong your problems with congestion when you try to stop using the decongestant.
  • Try taking an oral decongestant that contains pseudoephedrine. These are safer for prolonged use than decongestant nasal sprays.
  • Try using a non-prescription medication that thins mucus and improves sinus drainage (mucolytic). Guaifenesin is a commonly used mucolytic. Mucolytics are often combined with other medications such as cough suppressants.
  • Many doctors do not recommend using antihistamines unless your symptoms are related to having allergies. These medications may dry out the mucous membranes in your nose and sinuses and slow the movement of the cilia (the tiny hairs that line the nose, sinuses, and the air passages inside the lungs and that remove irritants). This can make mucus thicker, adding to drainage problems. However, other experts believe antihistamines may help treat sinusitis by reducing the amount of mucus that builds up in the sinus cavities.


Author: Amy Fackler, MA
Debby Golonka, MPH
Carrie Henley
Last Updated: May 14, 2007
Medical Review: Renée M. Crichlow, MD - Family Medicine
Martin Gabica, MD - Family Medicine
Kathleen Romito, MD - Family Medicine
Tom Bailey, MD - Family Medicine
Charles M. Myer, III, MD - Otolaryngology

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