Quinine sulfate for malaria

Examples

Generic Name
quinine sulfate plus an antibiotic such as doxycycline or tetracycline
quinine sulfate and clindamycin
quinine sulfate (rarely used alone)

How It Works

Quinine sulfate prevents the development of malaria parasites in the blood.

To treat malaria, you can take quinine sulfate alone for 3 to 7 days, but it is more commonly used in one of three different combinations:

  • Quinine sulfate plus doxycycline or tetracycline is taken for 7 days.
  • Quinine sulfate and clindamycin are taken for 7 days.

You usually take quinine sulfate as a tablet (orally).

Why It Is Used

Quinine sulfate plus another medication is the medication of choice for chloroquine-resistant malaria (where chloroquine is no longer effective against the malaria parasite).

How Well It Works

Quinine sulfate is effective against all species of Plasmodium.

Side Effects

Side effects of quinine sulfate include:

  • Nausea.
  • Blurred vision.
  • Headache.
  • Ringing in the ears.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Quinine sulfate given through a needle directly into a vein (intravenously, or IV) is not widely available in Canada, but intravenous quinidine gluconate, as a substitute, works just as well.

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Author: Maria G. Essig, MS, ELS
Carrie Henley
Last Updated: July 26, 2007
Medical Review: Martin Gabica, MD - Family Medicine
Anne C. Poinier, MD - Internal Medicine
W. David Colby IV, MSc, MD, FRCPC - Infectious Disease

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Topic Contents
 Examples
 How It Works
 Why It Is Used
 How Well It Works
 Side Effects
 What To Think About